Tumor Microenvironment and Therapy
The tumor micro-environment is increasingly recognized as a significant factor in cancer treatment response. Tumor oxygenation has long been known to influence sensitivity to drugs and radiation. Drug delivery is hindered by tumor vascular abnormalities and tumor desmoplasia. Recent work has uncovered means of circumventing or exploiting these changes that are unique to tumors for tumor-selective therapeutic strategies. Recent work also points to the potential for standard treatments to modulate host responses to tumors resulting in beneficial (immune responses) or counter-productive effects (vasculogenesis, tumor repopulation) on the tumor environment. This journal provides a forum for presenting the latest results of pre-clinical and clinical investigations into the role of the tumor microenvironment on therapy responses.
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