Genes, Chromosomes and Cancer
Gene Chromosome Canc
ISSN (printed): 1045-2257. ISSN (electronic): 1098-2264.
Genes Chromosomes & Cancer will offer rapid publication of original full-length research articles brief communications perspectives reviews letters to the editors as well as editorial commentaries on genetic analysis as related to the study of neoplasia. Particular emphasis will be placed on work combining molecular and cytogenetic analyses of the genomic alterations of cancer cells. While preference will be given to research using analytical approaches descriptive studies and case reports will also be welcomed particularly when they offer insights regarding basic biologic mechanisms or the clinical management of neoplastic disorders. Specific areas covered will include: Chromosomal abnormalities in all benign and malignant disorders including changes that occur during neoplastic progression Changes in gene structure and regulation as a consequence of genomic rearrangements Chromosomal alterations involving genes related to the regulation of cell proliferation and differentiation The correlation between genomic abnormalities and cellular phenotypic alterations The predictive value of alterations at the chromosomal and DNA levels in disease prognosis and in designing and monitoring cancer therapies Cytogenetic molecular and epidemiologic analyses of inherited disorders predisposing to cancer Chromosomal and/or genetic damage caused by external factors Descriptions of novel molecular biological and cytogenetic methods for genomic analysis.
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