Toxicology is a journal for the publication of original scientific papers on the biological effects arising from the administration of chemical compounds, principally to animals, tissues or cells, but also to man. Such compounds include industrial chemicals and residues, chemical contaminants, consumer products, drugs, metals, pesticides, food additives, cosmetics, and additives to animal feedstuff. Preference will be given to investigations dealing with the mechanisms of action of toxic agents. Papers describing molecular interactions with cellular and genetic processes will be welcomed.Quantitative toxicological studies will be published that are of relevance to risk assessment and regulatory management of exposure hazards and safety evaluation. This applies particularly to carcinogenicity, mutagenicity, embryotoxicity and related areas, as well as to alternatives to the use of animals in toxicological experimentation. Epidemiological studies bearing toxicological significance to man fall within the scope of the journal. The Editors also welcome the submission of concise and pertinent reviews on current issues in toxicology.IMMUNOTOXICOLOGY, a section of the journal, includes original papers and peer reviews dealing with any adverse interference of chemicals, including drugs, with the immune system: immunosuppression, hypersensitivity, auto-immunity, immune-mediated side-effects of drugs, toxicity of immunomodulating and immunotherapeutic agents. ENVIRONMENTAL AND NUTRITIONAL INTERACTIONS: A new section dedicated to original research and comprehensive critical reviews of animal as well as human and computer modeling studies of the interactions between the environment and nutrition. These include the effects of environmental changes on nutrition and food production; identification of nutrient interactions with environmentally induced disorders; the effect of nutritional status on the response to environmental stresses; and understanding the mechanisms of such interactions and their impact on human health and welfare. A list of forthcoming manuscripts is available on Internet via http://www.elsevier.nl/locate/toxicol-manuscripts.
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